Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• microenvironment. While several of these focused on stem cell differentiation [9][10], a couple of studies explored their effects on axonal guidance. Lee et al. [11] found that nanorough microridges composed of laser-patterned Al/Al2O3 nanowires increase cell attachment and effectively guide dorsal root ganglia

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• and regeneration [14]. Nanomaterials such as silver [15], gold [16][17], titanium oxide [18], zinc oxide [19][20], carbon nanotubes [21][22], graphene [23] and biosilica have been studied in terms of their osteogenic potential in stem cell differentiation. Chitosan materials are often combined with

• vitro cell interaction with mesenchymal stem cells through the p38 MAPK signalling pathway [17]. Gold nanoparticles show promising results in bone marrow mesenchymal stem cell differentiation towards osteogenic lineages, which might be due to the size and intrinsic factors of AuNPs. Mahmoud et al. (2020

• internal structure of cartilage. Human mesenchymal stem cell differentiation in 3D-printed scaffolds showed the differentiation ability of the cartilage tissue [128]. Future approaches Nanomaterials are widely used in the fabrication of scaffolds as they significantly mimic the extracellular matrix and

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

• Khosro Adibkia,
• Ali Ehsani,
• Asma Jodaei,
• Ezzatollah Fathi,
• Raheleh Farahzadi and
• Mohammad Barzegar-Jalali

Beilstein J. Nanotechnol. 2021, 12, 786–797, doi:10.3762/bjnano.12.62

• Akt phosphorylation in bovine endothelial cells [13]. It has been determined that the positive and negative effects of Ag-NPs entirely depend on size, time point, and cell type. Both positive and negative impacts of Ag-NPs on stem cell differentiation were previously reported by studies. In this

• initiate the differentiation into cell lineages such as cardiomyocytes, osteocytes, or chondrocytes [24]. Nanotechnology can boost stem cell differentiation and eliminate many obstacles thus improving its applicability in regenerative medicine [25]. The usage of nanomaterials in medicine has been

• considered previously and subsequent studies should identify relationships between nanomaterials and stem cell differentiation [26]. The potential effects of Ag-NPs on osteogenic and adipogenic differentiation of MSCs have been reported in other studies. In one study by Qin et al., it was shown that 4 µg/mL

Preparation of micro/nanopatterned gelatins crosslinked with genipin for biocompatible dental implants

• Reika Makita,
• Tsukasa Akasaka,
• Seiichi Tamagawa,
• Yasuhiro Yoshida,
• Saori Miyata,
• Hirofumi Miyaji and
• Tsutomu Sugaya

Beilstein J. Nanotechnol. 2018, 9, 1735–1754, doi:10.3762/bjnano.9.165

• of the surface of biomaterials. Surface topographical patterns significantly affect cell adhesion, spreading, morphology, proliferation, and differentiation [1][2][3][4][5]. Surfaces with specific micro/nanopatterns have been developed in order to reduce platelet response [6], to regulate stem cell

• differentiation [7], to functionalize implant surfaces [8][9], and to prevent the formation of bacterial biofilms [10]. In the dental field, we have used different micro/nanopatterns that employ an apatite paste [11], a flowable composite resin [12], a titanium coat [13], and curable dental materials [14]. The

Bioinspired self-healing materials: lessons from nature

• Joseph C. Cremaldi and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2018, 9, 907–935, doi:10.3762/bjnano.9.85

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

• Liga Saulite,
• Dominyka Dapkute,
• Karlis Pleiko,
• Ineta Popena,
• Simona Steponkiene,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2017, 8, 1218–1230, doi:10.3762/bjnano.8.123

• suggest that QD-labelled MSCs could be used for targeted drug delivery studies. Keywords: endocytosis; mesenchymal stem cells; quantum dots; stem cell differentiation; Introduction Despite remarkable advances in targeted therapies of various human malignancies, cancer is one of the leading causes of

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• expression, stem cell differentiation and even the epigenetic state of a cell (Figure 5) [10][12][79][185][186][187][188][189][190][191][192][193][194][195][196][197]. In vivo, the ECM where ECs and SMCs attach to, provide them micro- and nanotopographical stimuli to regulate their behavior [58]. Therefore

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• ex vivo and are therefore amenable to further treatment. Here, nanomaterials could provide a means of manipulating the fate of the stem cells, for example, by influencing migration in vivo by (over-)expression of homing receptors or influencing stem cell differentiation by providing the cells with an

Effect of silver nanoparticles on human mesenchymal stem cell differentiation

• Christina Sengstock,
• Jörg Diendorf,
• Matthias Epple,
• Thomas A. Schildhauer and
• Manfred Köller

Beilstein J. Nanotechnol. 2014, 5, 2058–2069, doi:10.3762/bjnano.5.214

• [19][21]. Therefore, it has been suggested that Ag-NP act as a “Trojan horse” that enables the release of metal ions within cells [42][43][44]. In this context, it is important to analyze the influence of subtoxic concentrations of nano-silver on stem cell differentiation after long-term incubation

• . Human MSCs may come into close contact with nano-silver, e.g., after the implantation of an Ag-NP-coated implant [17][45]. To date, little is known about the influence of nanoparticles on stem cell differentiation. In this study, we have shown that the adipogenic and osteogenic differentiation of hMSCs

• intracellular signaling structures is still not clear. Studies specifically investigating the effect of silver on stem cell differentiation are rare [49][50][58]. Albers et al. have shown that Ag-NP with a size of 50 nm also led to a concentration-dependent decrease in murine osteogenic cell differentiation [59